Adding some experience is 32-year-old Chelsea defender Gary Cahill, who has 58 caps, while Southgate has opted for both Trent Alexander-Arnold and Kieran Trippier as vibrant right-back options.
Alexander-Arnold, 19, has been rewarded for his impressive form both in the Premier League and in Liverpool‘s superb Champions League campaign.
It is certainly a nod to the new era, with Southgate including just five players — Jordan Henderson, Raheem Sterling, Danny Welbeck, Phil Jones and Cahill — who played in the last World Cup in 2014. Nobody in the squad has won a World Cup match.
Cahill, who hasn’t played in the last five England matches, has been given the nod despite appearing out of favour in the national set-up.
Liverpool’s Adam Lallana has not been included by Southgate following his troubles with hamstring injuries this season.
But it is a bold and youthful selection from Southgate, who has chosen a squad with an average age of just 26 years old.
Arsenal midfielder Wilshere was handed an international recall in March for the games against Holland and Italy, but was forced to withdraw 24 hours before the game in Amsterdam due to a minor knee injury and has not been able to make his way back into the fold.
‘I believe this is a squad which we can be excited about,’ Southgate said following the announcement.
‘It is a young group but with some really important senior players so I feel the balance of the squad is good, both in terms of its experience, its character and also the positional balance.
‘We have a lot of energy and athleticism in the team, but players that are equally comfortable in possession of the ball and I think people can see the style of play we’ve been looking to develop.
‘The selection process has been over months really, it’s not just been the last few weeks. We feel the team are improving and we want to continue that momentum.
‘The first call up for Trent Alexander-Arnold is well deserved. When we pick young players, it’s not just because they are young, it’s because their performances deserve it.
‘We’ve also had a couple of injuries with Alex Oxlade-Chamberlain and Joe Gomez, which is a huge blow for them personally and disappointing for us.’
Elsewhere, Fabian Delph was named in the squad in place of Wilshere following his role in Manchester City’s title-winning campaign.
Manchester United’s Ashley Young and Danny Rose of Tottenham are England’s recognised left backs, which means Southampton’s Ryan Bertrand is placed on the standby list.
Chelsea midfielder Ruben Loftus-Cheek, who spent the season on loan at Crystal Palace, also gains a place in the squad.
Tom Heaton, James Tarkowski, Lewis Cook, Jake Livemore and Adam Lallana have all been formally put on standby.
An attacking quartet of Harry Kane, Jamie Vardy, Marcus Rashford and Welbeck will make up England’s offensive options at Russia.
They kick off their campaign against Tunisia on June 18 before subsequent group games against Panama and Belgium.